Document Detail

Pathogenesis of varicose veins.
MedLine Citation:
PMID:  22030459     Owner:  NLM     Status:  MEDLINE    
Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.
Rahmi Oklu; Roy Habito; Manuel Mayr; Amy R Deipolyi; Hassan Albadawi; Robin Hesketh; T Gregory Walker; Katy R Linskey; Chandler A Long; Stephan Wicky; Julianne Stoughton; Michael T Watkins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-10-26
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  23     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-06     Completed Date:  2012-05-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-9; quiz 40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Biological Markers / metabolism
Genetic Predisposition to Disease
Muscle, Smooth, Vascular / pathology*
Risk Factors
Transforming Growth Factor beta / metabolism
Varicose Veins / etiology*,  genetics,  metabolism,  pathology*
Grant Support
FS/08/002/24537//British Heart Foundation
Reg. No./Substance:
0/Biological Markers; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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