| The pathogenesis and treatment of acute spinal cord injuries in dogs. | |
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MedLine Citation:
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PMID: 20732592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mechanical damage to the spinal cord initiates a secondary injury cascade that results in ischemia, disturbances in ion concentrations, excitotoxicity, production of reactive oxygen species, inflammation, and apoptosis. Over weeks to months a glial scar forms, and scarring can result in the development of syringomyelia. In the early phase of the disease, treatment should focus on maintaining systemic blood pressure and oxygenation, decompression of the spinal cord, and stabilization, if indicated. There are currently no proven neuroprotective drug therapies for limiting secondary damage, but blinded clinical trials are underway. Transplantation with olfactory ensheathing cells and mesenchymal stem cells show promise, as do potassium channel antagonists. Canine clinical trials of these therapies are ongoing. |
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Authors:
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Natasha Olby |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Veterinary clinics of North America. Small animal practice Volume: 40 ISSN: 1878-1306 ISO Abbreviation: Vet. Clin. North Am. Small Anim. Pract. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7809942 Medline TA: Vet Clin North Am Small Anim Pract Country: United States |
Other Details:
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Languages: eng Pagination: 791-807 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA. Natasha_olby@ncsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Clinical Trials as Topic Dogs / injuries* Female Male Mesenchymal Stem Cell Transplantation / veterinary Myelitis / prevention & control, veterinary Neuroprotective Agents / therapeutic use Spinal Cord Injuries / pathology, therapy, veterinary* Spinal Cord Regeneration Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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