Document Detail


The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research.
MedLine Citation:
PMID:  22789861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The equine superficial digital flexor tendon (SDFT) is a frequently injured structure that is functionally and clinically equivalent to the human Achilles tendon (AT). Both act as critical energy-storage systems during high-speed locomotion and can accumulate exercise- and age-related microdamage that predisposes to rupture during normal activity. Significant advances in understanding of the biology and pathology of exercise-induced tendon injury have occurred through comparative studies of equine digital tendons with varying functions and injury susceptibilities. Due to the limitations of in-vivo work, determination of the mechanisms by which tendon cells contribute to and/or actively participate in the pathogenesis of microdamage requires detailed cell culture modelling. The phenotypes induced must ultimately be mapped back to the tendon tissue environment. The biology of tendon cells and their matrix, and the pathological changes occurring in the context of early injury in both horses and people are reviewed, with a particular focus on the use of various tendon cell and tissue culture systems to model these events.
Authors:
J C Patterson-Kane; D L Becker; T Rich
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-11
Journal Detail:
Title:  Journal of comparative pathology     Volume:  147     ISSN:  1532-3129     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2012 Aug-Oct
Date Detail:
Created Date:  2012-08-03     Completed Date:  2013-01-22     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-47     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Achilles Tendon / injuries*
Animals
Athletic Injuries / pathology*
Disease Models, Animal
Horse Diseases*
Horses
Humans
Lameness, Animal
Research Design
Rupture / pathology,  veterinary*
Tendon Injuries / pathology,  veterinary*
Grant Support
ID/Acronym/Agency:
BB/J000655/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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