| The pathogenesis of sepsis. | |
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MedLine Citation:
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PMID: 20887193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sepsis is a serious clinical condition that represents a patient's response to a severe infection and has a very high mortality rate. Normal immune and physiologic responses eradicate pathogens, and the pathophysiology of sepsis is due to the inappropriate regulation of these normal reactions. In an ideal scenario, the first pathogen contact with the inflammatory system should eliminate the microbe and quickly return the host to homeostasis. The septic response may accelerate due to continued activation of neutrophils and macrophages/monocytes. Upregulation of lymphocyte costimulatory molecules and rapid lymphocyte apoptosis, delayed apoptosis of neutrophils, and enhanced necrosis of cells/tissues also contribute to the pathogenesis of sepsis. The coagulation system is closely tied to the inflammatory response, with cross talk between the two systems driving the dysregulated response. Biomarkers may be used to help diagnose patients with sepsis, and they may also help to identify patients who would benefit from immunomodulatory therapies. |
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Authors:
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Deborah J Stearns-Kurosawa; Marcin F Osuchowski; Catherine Valentine; Shinichiro Kurosawa; Daniel G Remick |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Annual review of pathology Volume: 6 ISSN: 1553-4014 ISO Abbreviation: Annu Rev Pathol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-25 Completed Date: 2011-04-25 Revised Date: 2012-03-14 |
Medline Journal Info:
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Nlm Unique ID: 101275111 Medline TA: Annu Rev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 19-48 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Massachusetts 02218, USA. dstearns@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Biological Markers* Blood Coagulation / immunology* Critical Illness* Female Humans Middle Aged Sepsis / immunology*, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM082962-03/GM/NIGMS NIH HHS; R01 GM082962-04/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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