Document Detail

Pathogenesis of Rh immunization in primigravidas. Fetomaternal versus maternofetal bleeding.
MedLine Citation:
PMID:  401536     Owner:  NLM     Status:  MEDLINE    
Rh immunization occurring during a first pregnancy with no history of preceding abortion or transfusion may result when Rh incompatible fetal to maternal bleeding ensues early enough in the gestation to initiate a maternal immune response before parturition. Alternatively, the initial antigenic stimulus could be the consequence of maternal to fetal transfer of Rh-incompatible erythrocytes while the patient herself was in utero or at the time of her own delivery. These hypotheses were tested by 1) analysis of the blood group and Rh of 22 Rh-immunized primigravidas, their infants, and their own mothers; 2) comparison of the number of fetal cells in the maternal circulation during the antepartum period in 20 women at high risk for fetal to maternal bleeding with their matched controls; and 3) Rho (D) antibody determinations in 70 Rh-negative infants born to Rh-positive mothers. The results indicate that antepartum fetal to maternal bleeding is the usual cause of Rh immunization in primigravidas, and the Rh-negative woman with blood group A, B, or AB who gestates an ABO-compatible Rh-positive male is at highest risk. The antepartum use of anti-Rho (D) immune globulin has potential prophylactic value in this situation.
J R Scott; A E Beer; L R Guy; M Liesch; G Elbert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  49     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  AIM; IM    
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MeSH Terms
ABO Blood-Group System
Antibody Formation*
Blood Group Incompatibility / immunology
Fetomaternal Transfusion*
Gestational Age
Infant, Newborn
Maternal-Fetal Exchange
Rh-Hr Blood-Group System*
Reg. No./Substance:
0/ABO Blood-Group System; 0/Isoantibodies; 0/Rh-Hr Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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