| The pathogenesis of primary cicatricial alopecias. | |
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MedLine Citation:
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PMID: 20889564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cicatricial (scarring) alopecia results from irreversible damage to epithelial stem cells located in the bulge region of the hair follicle, generally as a result of inflammatory mechanisms (eg, in the context of autoimmune disease). In primary cicactricial alopecia (PCA), the hair follicle itself is the key target of autoaggressive immunity. This group of permanent hair loss disorders can be classified into distinct subgroups, characterized by the predominant peri-follicular inflammatory cell type. In none of these PCA forms do we know exactly why hair follicles begin to attract such an infiltrate. Thus, it is not surprising that halting or even reversing this inflammation in PCA is often extremely difficult. However, increasing evidence suggests that healthy hair follicle epithelial stem cells enjoy relative protection from inflammatory assault by being located in an immunologically "privileged" niche. Because this protection may collapse in PCA, one key challenge in PCA research is to identify the specific signaling pathways that endanger, or restore, the relative immunoprotection of these stem cells. After a summary of pathobiological principles that underlie the development and clinical phenotype of PCA, we close by defining key open questions that need to be answered if more effective treatment modalities for this therapeutically very frustrating, but biologically fascinating, group of diseases are to be developed. |
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Authors:
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Matthew J Harries; Ralf Paus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-01 |
Journal Detail:
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Title: The American journal of pathology Volume: 177 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2011-03-21 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 2152-62 Citation Subset: AIM; IM |
Affiliation:
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Dermatology Centre, University of Manchester, Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alopecia
/
etiology,
immunology,
pathology*,
physiopathology* Animals Autoimmune Diseases / complications, pathology Cicatrix / pathology* Disease Models, Animal Epithelial Cells / cytology, physiology Hair Follicle / cytology, pathology* Humans Inflammation / complications, pathology PPAR gamma / deficiency Stem Cells / immunology |
| Chemical | |
Reg. No./Substance:
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0/PPAR gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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