| Pathogenesis of Kawasaki disease. | |
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MedLine Citation:
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PMID: 21447126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kawasaki disease (KD) most frequently affects infants and young children under 5 years of age. This disease is considered a kind of systemic vasculitis syndrome, and primarily invades the medium-sized muscular arteries, including coronary arteries. Diagnosis of KD is based on characteristic clinical signs and symptoms, which are classified as principal clinical findings and other clinical and laboratory findings. Even though the aetiology of KD is unknown, epidemiological data suggest that some kinds of infectious agents are involved in the onset of KD. In addition, the data indicate that host genetics underlie the disease's pathogenesis. Histologically, coronary arteritis begins 6-8 days after the onset of KD, and leads immediately to inflammation of all layers of the artery. The inflammation spreads completely around the artery; as a result, structural components of the artery undergo intense damage; the artery then begins to dilate. Inflammatory cell infiltration continues until about the 25th day of the disease, after which the inflammatory cells gradually decrease in number. KD arteritis is characterized by granulomatous inflammation that consists of severe accumulation of monocytes/macrophages. Aberrant activation of monocytes/macrophages is thought to be involved in the formation of vascular lesions. The lesions in all the arteries are relatively synchronous as they evolve from acute to chronic injury. There is no fibrinoid necrosis nor any mixture of acute inflammatory lesions and scarring lesions, which are characteristics in polyarteritis nodosa in KD. |
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Authors:
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K Takahashi; T Oharaseki; Y Yokouchi |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 164 Suppl 1 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-30 Completed Date: 2011-04-27 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 20-2 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors;Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
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Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan. keitak@oha.toho-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Chronic Disease Cicatrix / immunology Coronary Artery Disease / etiology, immunology*, pathology Humans Immunoglobulins, Intravenous / therapeutic use Immunologic Factors / therapeutic use Macrophage Activation / immunology Macrophages / immunology Mucocutaneous Lymph Node Syndrome / complications, immunology*, pathology, therapy Polyarteritis Nodosa / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 0/Immunologic Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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