Document Detail

Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. II. Estimated age at disease onset.
MedLine Citation:
PMID:  3710729     Owner:  NLM     Status:  MEDLINE    
The presence of a layer of abnormal material in Descemet's membrane in eight keratoplasty specimens served as a marker to determine whether Chandler's syndrome, Essential Iris Atrophy, and the Cogan-Reese syndrome are congenital or acquired conditions. In all eight cases of the ICE syndrome, a pattern of membrane deposition was observed, which typifies acquired disorders: a completely normal prenatal layer and both normal and abnormal portions of the postnatal layer. The thickness of the membrane deposited before the onset of abnormal secretion was used to estimate a time span for possible ages at which abnormal secretion began. The estimated age intervals for all diseased specimens had their lower limits in the postnatal period. Thus, these results led us to the conclusion that abnormal Descemet's membrane first appeared in postnatal life, years before clinical recognition of disease. The possibility of a viral etiology for this unilateral endotheliopathy resulting in an altered Descemet's membrane is discussed.
J A Alvarado; C G Murphy; R P Juster; J Hetherington
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  27     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-09     Completed Date:  1986-07-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  873-82     Citation Subset:  IM    
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MeSH Terms
Age Factors
Atrophy / complications,  pathology,  physiopathology
Corneal Diseases / complications*,  pathology,  physiopathology
Corneal Stroma / pathology
Descemet Membrane / embryology,  growth & development,  pathology,  secretion
Iris / pathology*
Iris Diseases / complications*,  pathology,  physiopathology
Middle Aged
Reference Values
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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