Document Detail


Pathogenesis of accelerated fibrosis in HIV/HCV co-infection.
MedLine Citation:
PMID:  23390300     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus (HIV) infection is a major cause of acceleration of hepatitis C virus-related liver disease, cirrhosis, and death. However, studies of liver disease pathogenesis in HIV/HCV coinfection have thus far been limited. Emerging data support multiple derangements attending HIV coinfection, including increases in profibrogenic cytokine expression and secretion, generation of enhanced oxidative stress, and increases in hepaotcyte apoptosis. These derangements may be further augmented in the presence of increased microbial translocation in the setting of HIV disease. New insight into the mechanisms of HIV/HCV pathogenesis causing accelerated liver fibrosis could lead to new therapeutic strategies designed to retard ths process.
Authors:
Wenyu Lin; Ethan M Weinberg; Raymond T Chung
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  207 Suppl 1     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-04-01     Revised Date:  2014-07-04    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S13-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Bacterial Translocation
Coinfection / pathology*
Cytokines / secretion
HIV Infections / complications*,  pathology*
Hepatitis C / complications*,  pathology*
Humans
Liver Cirrhosis / pathology*
Oxidative Stress
Grant Support
ID/Acronym/Agency:
AI069939/AI/NIAID NIH HHS; DK098079/DK/NIDDK NIH HHS; R01 DK098079/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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