Document Detail


Pathogen-induced programmed cell death in tobacco.
MedLine Citation:
PMID:  9202394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sacrificing an infected cell or cells in order to prevent systemic spread of a pathogen appears to be a conserved strategy in both plants and animals. We studied some of the morphological and biochemical events that accompany programmed cell death during the hypersensitive response of tobacco plants infected with tobacco mosaic virus. Certain aspects of this cell death process appeared to be similar to those that take place during apoptosis in animal cells. These included condensation and vacuolization of the cytoplasm and cleavage of nuclear DNA to 50 kb fragments. In contrast, internucleosomal fragmentation, condensation of chromatin at the nuclear periphery and apoptotic bodies were not observed in tobacco plants during tobacco mosaic virus-induced hypersensitive response. A unique aspect of programmed cell death during the hypersensitive response of tobacco to tobacco mosaic virus involved an increase in the amount of monomeric chloroplast DNA. Morphological changes to the chloroplast and cytosol of tobacco cells and increase in monomeric chloroplast DNA occurred prior to gross changes in nuclear morphology and significant chromatin cleavage. Our findings suggest that certain aspects of programmed cell death may have been conserved during the evolution of plants and animals.
Authors:
R Mittler; L Simon; E Lam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of cell science     Volume:  110 ( Pt 11)     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-09-29     Completed Date:  1997-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1333-44     Citation Subset:  IM    
Affiliation:
Center for Agricultural Molecular Biology, Rutgers The State University of New Jersey, Cook College, New Brunswick 08903-0231, USA.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
Chromatin / metabolism
DNA Fragmentation
DNA, Chloroplast / metabolism
Electrophoresis / methods
Microscopy, Electron
Plant Diseases* / virology
Plants, Toxic*
Tobacco / cytology*,  ultrastructure,  virology
Tobacco Mosaic Virus
Chemical
Reg. No./Substance:
0/Chromatin; 0/DNA, Chloroplast

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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