Document Detail

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.
MedLine Citation:
PMID:  18523652     Owner:  NLM     Status:  MEDLINE    
Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreographed vesicular fusion and fission events. The objectives of this review are to highlight the functional importance of lipids in the phagocytic process, to discuss how pathogenic microorganisms can in some cases manipulate host lipid metabolism to either co-opt or disrupt phagosome maturation and promote their own survival, and to describe how defective phagosomal lipid metabolism can result in disease.
Benjamin E Steinberg; Sergio Grinstein
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  118     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-07-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2002-11     Citation Subset:  AIM; IM    
Program in Cell Biology, Hospital for Sick Children, Institute of Medical Science and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Cell Survival
Cytoskeleton / metabolism
Endosomes / metabolism
Lipid Metabolism
Lipids / chemistry*
Models, Biological
Mycobacterium tuberculosis / metabolism
Peptides / chemistry
Phagosomes / metabolism*
Protein Structure, Tertiary
Reg. No./Substance:
0/Lipids; 0/Peptides

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