Document Detail


Pathobionts of the gastrointestinal microbiota and inflammatory disease.
MedLine Citation:
PMID:  21856139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our immune system is charged with the vital mission of identifying invading pathogens and mounting proper inflammatory responses. During the process of clearing infections, the immune system often causes considerable tissue damage. Conversely, if the target of immunity is a member of the resident microbiota, uncontrolled inflammation may lead to host pathology in the absence of infectious agents. Recent evidence suggests that several inflammatory disorders may be caused by specific bacterial species found in most healthy hosts. Although the mechanisms that mediate pathology remain largely unclear, it appears that genetic defects and/or environmental factors may predispose mammals to immune-mediated diseases triggered by potentially pathogenic symbionts of the microbiota. We have termed this class of microbes 'pathobionts', to distinguish them from acquired infectious agents. Herein, we explore burgeoning hypotheses that the combination of an immunocompromised state with colonization by pathobionts together comprise a risk factor for certain inflammatory disorders and gastrointestinal (GI) cancer.
Authors:
Janet Chow; Haiqing Tang; Sarkis K Mazmanian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-17
Journal Detail:
Title:  Current opinion in immunology     Volume:  23     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2011-11-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  473-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / adverse effects,  therapeutic use
Bacteria / immunology,  pathogenicity
Cocarcinogenesis
Colorectal Neoplasms / etiology,  microbiology
Enterocolitis, Pseudomembranous / etiology,  microbiology
Gastrointestinal Tract / microbiology*
Genetic Predisposition to Disease
Helicobacter / immunology,  pathogenicity
Host-Pathogen Interactions / immunology,  physiology*
Humans
Immunocompromised Host
Inflammatory Bowel Diseases / etiology*,  immunology,  microbiology,  physiopathology
Metagenome / immunology,  physiology*
Mice
Mice, SCID
Models, Biological
Species Specificity
Superinfection
Symbiosis
Grant Support
ID/Acronym/Agency:
AI088626/AI/NIAID NIH HHS; DK078938/DK/NIDDK NIH HHS; DK083633/DK/NIDDK NIH HHS; GM007616/GM/NIGMS NIH HHS; R01 DK078938/DK/NIDDK NIH HHS; R01 DK078938-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents
Comments/Corrections

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