| Pathobionts of the gastrointestinal microbiota and inflammatory disease. | |
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MedLine Citation:
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PMID: 21856139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our immune system is charged with the vital mission of identifying invading pathogens and mounting proper inflammatory responses. During the process of clearing infections, the immune system often causes considerable tissue damage. Conversely, if the target of immunity is a member of the resident microbiota, uncontrolled inflammation may lead to host pathology in the absence of infectious agents. Recent evidence suggests that several inflammatory disorders may be caused by specific bacterial species found in most healthy hosts. Although the mechanisms that mediate pathology remain largely unclear, it appears that genetic defects and/or environmental factors may predispose mammals to immune-mediated diseases triggered by potentially pathogenic symbionts of the microbiota. We have termed this class of microbes 'pathobionts', to distinguish them from acquired infectious agents. Herein, we explore burgeoning hypotheses that the combination of an immunocompromised state with colonization by pathobionts together comprise a risk factor for certain inflammatory disorders and gastrointestinal (GI) cancer. |
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Authors:
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Janet Chow; Haiqing Tang; Sarkis K Mazmanian |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-08-17 |
Journal Detail:
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Title: Current opinion in immunology Volume: 23 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-29 Completed Date: 2011-11-10 Revised Date: 2012-09-27 |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 473-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / adverse effects, therapeutic use Bacteria / immunology, pathogenicity Cocarcinogenesis Colorectal Neoplasms / etiology, microbiology Enterocolitis, Pseudomembranous / etiology, microbiology Gastrointestinal Tract / microbiology* Genetic Predisposition to Disease Helicobacter / immunology, pathogenicity Host-Pathogen Interactions / immunology, physiology* Humans Immunocompromised Host Inflammatory Bowel Diseases / etiology*, immunology, microbiology, physiopathology Metagenome / immunology, physiology* Mice Mice, SCID Models, Biological Species Specificity Superinfection Symbiosis |
| Grant Support | |
ID/Acronym/Agency:
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AI088626/AI/NIAID NIH HHS; DK078938/DK/NIDDK NIH HHS; DK083633/DK/NIDDK NIH HHS; GM007616/GM/NIGMS NIH HHS; R01 DK078938-04/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
| Comments/Corrections | |
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