Document Detail

Pathobiological features of small hepatocellular carcinoma: correlation between tumor size and biological behavior.
MedLine Citation:
PMID:  20508947     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: Increasing evidence has suggested that tumor size is one of the independent prognostic factors of patients with hepatocellular carcinoma (HCC). However, the criteria used to determine when HCC should be classified as small remain controversial. Our objective was to evaluate the relationship between the size of HCC and its clinicopathological features.
METHODS: A retrospective study on 618 patients who underwent partial hepatectomy for solitary HCC was performed. These patients were divided into Groups 1-5 according to the tumor diameter: ≤1, 1.1-2, 2.1-3, 3.1-5 and >5 cm, respectively. The clinicopathological variables of the patients in each group were compared statistically.
RESULTS: Except for the microHCC (≤1 cm) which differed significantly from the other four groups in the clinicopathological variables, almost no differences existed among HCC ranging from 1 to 3 cm, or HCCs > 3 cm. If ≤3 cm was used as the cut-off point for small HCC (SHCC), and >3 cm for large HCC (LHCC), significant differences (P < 0.05-0.01) were observed between SHCC and LHCC in: histological grades I-II (48.0 vs. 19.4 %), capsular invasion (15.4 vs. 36.3%), tumor thrombi (6.9 vs. 23.5%), satellite nodules (12.3 vs. 35.5%), noninvasive growth patterns (69.6 vs. 25.4%), the overall survival (OS, 119.6 ± 34.7 vs. 68.5 ± 6.6 months), and the recurrence-free survival (RFS, 67.0 ± 16.7 vs. 29.5 ± 3.2 months). Multivariate Cox regression analyses show that tumor size >3 cm was one of the independent prognostic factors for both OS and RFS.
CONCLUSIONS: The 3 cm cutoff seems to best determine the biological behavior and clinical prognosis of patients undergoing partial hepatectomy for early stage HCC. Overall, HCC smaller than 3 cm in diameter was closely related with a better prognosis which reflected the relatively benign pathobiological features at an early developmental stage. As HCC > 3 cm exhibited a tendency towards more aggressive behavior, we suggest that HCC ≤ 3 cm in diameter should be used as a critical size of SHCC at which curative treatment achieves better long-term survivals.
Xin-Yuan Lu; Tao Xi; Wan-Yee Lau; Hui Dong; Zhi-Hong Xian; Hua Yu; Zhen Zhu; Feng Shen; Meng-Chao Wu; Wen-Ming Cong
Related Documents :
14734147 - Report of the 15th follow-up survey of primary liver cancer.
19760957 - Evaluation of new prognostic staging systems (slide score) for hepatocellular carcinoma...
16608037 - Diffuse infiltrative hepatocellular carcinomas in a hepatitis b-endemic area: diagnosti...
18414167 - Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (o...
3924867 - The influence of field size, treatment modality, commissure involvement and histology i...
22072307 - A multicenter, randomized, phase 2 clinical trial to evaluate the efficacy and safety o...
Publication Detail:
Type:  Journal Article     Date:  2010-05-28
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  137     ISSN:  1432-1335     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  567-75     Citation Subset:  IM    
Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nucleotide excision repair polymorphisms and survival outcome for patients with metastatic breast ca...
Next Document:  Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases.