Document Detail


The path from skin to brain: generation of functional neurons from fibroblasts.
MedLine Citation:
PMID:  22614130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of particular interest because of the potential to treat diseases of the nervous system, such as neurodegenerative disorders and spinal cord injuries, with cell replacement therapy. Recent advances in cell fate reprogramming have led to the development of novel methods for the direct conversion of fibroblasts into neurons and neural stem cells. This review will highlight the advantages of these new methods over neuronal induction from embryonic stem cells and induced pluripotent stem cells, as well as outline the limitations and the potential for future applications.
Authors:
Aisha Iman Abdullah; Andrew Pollock; Tao Sun
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-22
Journal Detail:
Title:  Molecular neurobiology     Volume:  45     ISSN:  1559-1182     ISO Abbreviation:  Mol. Neurobiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-22     Completed Date:  2012-10-17     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  8900963     Medline TA:  Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-95     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA. aia2005@med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology*
Fibroblasts / cytology*,  metabolism
Humans
Induced Pluripotent Stem Cells / cytology,  metabolism
Neurogenesis
Neurons / cytology*,  metabolism
Skin / cytology*
Grant Support
ID/Acronym/Agency:
R01 MH083680/MH/NIMH NIH HHS; R01-MH083680/MH/NIMH NIH HHS
Comments/Corrections

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