Document Detail

Path analysis on the risk of mortality in very low birth weight infants.
MedLine Citation:
PMID:  10959941     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this work is to clarify by path analysis which of the predictor factors of mortality in a cohort of 423 singletons VLBW infants born at Beilinson Medical Center during the years 1980-1990 (pre-surfactant era) exert direct or indirect effect on mortality. A direct risk factor was defined as a factor having an immediate effect on the outcome without working through an intermediate variable. By contrast, an indirect risk factor was defined as a factor that does not have a direct effect on the risk of mortality but instead works through an intermediate variable. Evaluation of mortality was done at three points over time (pre-delivery, at birth and post-delivery). RESULTS: In the pre-delivery model, gestational age, appropriateness for gestational age, mother's age and fetal distress work directly on mortality in VLBW infants. At birth, mother's age, birth weight and Apgar score at the fifth minute work directly on the risk of mortality. When the assessment of the risk of death was done post-delivery, mother's age, birth weight, Apgar score at the fifth minute and seizures influence directly on mortality risk, and fetal distress, gestational age and pre-natal induced hypertension (PIH) operate indirectly on the risk of mortality. CONCLUSION: The methodology we have used can be adopted in other investigations to distinguish and measure the effect of prognostic factors on the risk of an outcome.
J Sulkes; S Fields; U Gabbay; M Hod; P Merlob
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of epidemiology     Volume:  16     ISSN:  0393-2990     ISO Abbreviation:  Eur. J. Epidemiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8508062     Medline TA:  Eur J Epidemiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Epidemiology Unit, Rabin Medical Center, Petach Tikva, Israel.
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MeSH Terms
Infant Mortality*
Infant, Newborn
Infant, Very Low Birth Weight*
Israel / epidemiology
Survival Analysis*

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