| Paternal use of ribavirin-interferon alpha 2B combination therapy before conception. | |
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MedLine Citation:
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PMID: 16805078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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QUESTION: One of my male patients is receiving ribavirin-interferon alpha 2B (Pegetron) combination therapy for chronic hepatitis C. His wife recently found out she is 6 weeks pregnant. They are concerned that the medications might have affected his sperm. How should I advise them? ANSWER: To the best of our knowledge, paternal exposure to ribavirin-interferon alpha 2B has no adverse effects on reproduction. Although we do not have sufficient information to confirm this, several pregnancies where the father had been exposed to these medications turned out fine. If an unexpected pregnancy occurs while the father is receiving this therapy, there is no medical indication for terminating the pregnancy. |
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Authors:
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Nobuko Taguchi; Shinya Ito |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Canadian family physician Médecin de famille canadien Volume: 51 ISSN: 0008-350X ISO Abbreviation: Can Fam Physician Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-06-29 Completed Date: 2006-07-28 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 0120300 Medline TA: Can Fam Physician Country: Canada |
Other Details:
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Languages: eng Pagination: 1623-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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administration & dosage,
adverse effects* Drug Combinations Female Hepatitis C, Chronic / drug therapy* Humans Interferon-alpha / administration & dosage, adverse effects* Male Paternal Exposure / adverse effects* Pregnancy Recombinant Proteins Ribavirin / administration & dosage, adverse effects* Spermatozoa / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Drug Combinations; 0/Interferon-alpha; 0/Recombinant Proteins; 36791-04-5/Ribavirin; 99210-65-8/interferon alfa-2b |
| Comments/Corrections | |
Comment In:
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Can Fam Physician. 2007 Mar;53(3):401; author reply 401-2
[PMID:
17872667
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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