Document Detail

Paternal use of ribavirin-interferon alpha 2B combination therapy before conception.
MedLine Citation:
PMID:  16805078     Owner:  NLM     Status:  MEDLINE    
QUESTION: One of my male patients is receiving ribavirin-interferon alpha 2B (Pegetron) combination therapy for chronic hepatitis C. His wife recently found out she is 6 weeks pregnant. They are concerned that the medications might have affected his sperm. How should I advise them?
ANSWER: To the best of our knowledge, paternal exposure to ribavirin-interferon alpha 2B has no adverse effects on reproduction. Although we do not have sufficient information to confirm this, several pregnancies where the father had been exposed to these medications turned out fine. If an unexpected pregnancy occurs while the father is receiving this therapy, there is no medical indication for terminating the pregnancy.
Nobuko Taguchi; Shinya Ito
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  51     ISSN:  0008-350X     ISO Abbreviation:  Can Fam Physician     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-06-29     Completed Date:  2006-07-28     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1623-5     Citation Subset:  IM    
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MeSH Terms
Antiviral Agents / administration & dosage,  adverse effects*
Drug Combinations
Hepatitis C, Chronic / drug therapy*
Interferon-alpha / administration & dosage,  adverse effects*
Paternal Exposure / adverse effects*
Recombinant Proteins
Ribavirin / administration & dosage,  adverse effects*
Spermatozoa / drug effects
Reg. No./Substance:
0/Antiviral Agents; 0/Drug Combinations; 0/Interferon-alpha; 0/Recombinant Proteins; 36791-04-5/Ribavirin; 99210-65-8/interferon alfa-2b
Comment In:
Can Fam Physician. 2007 Mar;53(3):401; author reply 401-2   [PMID:  17872667 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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