Document Detail


Paternal thrombophilic gene mutations are not associated with recurrent miscarriage.
MedLine Citation:
PMID:  18754836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: Recurrent miscarriage (RM) affects 1-3% of couples. So far, diagnostic procedures are performed only in female patients. However, the main part of the placentary perfusion is encoded by both the maternal and the paternal genome. METHOD OF STUDY: In this case-control study, German couples with two (n = 49) or three and more RM (n = 102) and 157 German control couples were analyzed for the factor V-Leiden 169 1G > A mutation (FVL), the prothrombin (PT) 202 10G > A substitution, and the 677C > T replacement in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene. RESULTS: No significant differences in the prevalence of the FVL, PT or MTHFR mutation were observed in male partners of RM patients and in control men [RM/control: FVL heterozygous 13/151 (8.6%): 14/157 (8.9%) (P = 0.9); PT heterozygous 2/151 (1.3%): 7/157 (4.5%) (P = 0.097); PT homozygous 0/151: 2/157 (1.3%); MTHFR homozygous 19/151 (12.6%): 18/157 (11.5%) (P = 0.12)]. This was also true for female RM patients. However, miscarriage during the embryonal period (5-10 weeks of gestation) was significantly associated with a maternal heterozygous FVL mutation (P = 0.014). CONCLUSION: Recurrent miscarriage was not associated with paternal thrombophilia. Men of the control group showed an even higher incidence of the PT and MTHFR mutations. Abortions in the embryonic phase of fetal development were associated with a significantly higher incidence of maternal heterozygosity for FVL.
Authors:
Bettina Toth; Franziska Vocke; Nina Rogenhofer; Klaus Friese; Christian J Thaler; Peter Lohse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  60     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-12-12     Completed Date:  2009-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Grosshadern, Ludwig-Maximilians-University, Munich, Germany. bettina.toth@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*
Adult
Aged
Aged, 80 and over
Case-Control Studies
Factor V / genetics*
Fathers
Female
Genotype
Humans
Male
Middle Aged
Mutation / genetics
Pregnancy
Pregnancy Complications, Hematologic / genetics*
Prothrombin / genetics*
Thrombophilia / genetics*
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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