Document Detail

Paternal thrombophilic gene mutations are not associated with recurrent miscarriage.
MedLine Citation:
PMID:  18754836     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Recurrent miscarriage (RM) affects 1-3% of couples. So far, diagnostic procedures are performed only in female patients. However, the main part of the placentary perfusion is encoded by both the maternal and the paternal genome. METHOD OF STUDY: In this case-control study, German couples with two (n = 49) or three and more RM (n = 102) and 157 German control couples were analyzed for the factor V-Leiden 169 1G > A mutation (FVL), the prothrombin (PT) 202 10G > A substitution, and the 677C > T replacement in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene. RESULTS: No significant differences in the prevalence of the FVL, PT or MTHFR mutation were observed in male partners of RM patients and in control men [RM/control: FVL heterozygous 13/151 (8.6%): 14/157 (8.9%) (P = 0.9); PT heterozygous 2/151 (1.3%): 7/157 (4.5%) (P = 0.097); PT homozygous 0/151: 2/157 (1.3%); MTHFR homozygous 19/151 (12.6%): 18/157 (11.5%) (P = 0.12)]. This was also true for female RM patients. However, miscarriage during the embryonal period (5-10 weeks of gestation) was significantly associated with a maternal heterozygous FVL mutation (P = 0.014). CONCLUSION: Recurrent miscarriage was not associated with paternal thrombophilia. Men of the control group showed an even higher incidence of the PT and MTHFR mutations. Abortions in the embryonic phase of fetal development were associated with a significantly higher incidence of maternal heterozygosity for FVL.
Bettina Toth; Franziska Vocke; Nina Rogenhofer; Klaus Friese; Christian J Thaler; Peter Lohse
Related Documents :
19912516 - Low molecular weight heparin to achieve live birth following unexplained pregnancy loss...
11525866 - Medical treatment of a central vein suppurative thrombosis with cerebral metastatic abs...
25318796 - Pregnancy and delivery in women with renovascular hypertension due to multiple intraren...
20579956 - Idiopathic recurrent pregnancy loss recurs at similar gestational ages.
20847186 - Identification of copy number variants in miscarriages from couples with idiopathic rec...
21994486 - Newborn interneurons in the accessory olfactory bulb promote mate recognition in female...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  60     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-12-12     Completed Date:  2009-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortion, Habitual / genetics*
Aged, 80 and over
Case-Control Studies
Factor V / genetics*
Middle Aged
Mutation / genetics
Pregnancy Complications, Hematologic / genetics*
Prothrombin / genetics*
Thrombophilia / genetics*
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antidepressant use and suicide prevention: a prescription database study in the region Friuli Venezi...
Next Document:  Leukocyte subpopulation in ascites of women with pre-eclampsia.