Document Detail


Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study.
MedLine Citation:
PMID:  22782864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Several epidemiological studies have suggested that certain paternal occupations may be associated with an increased prevalence of birth defects in offspring. Using data from the National Birth Defects Prevention Study, the authors investigated the association between paternal occupation and birth defects in a case-control study of cases comprising over 60 different types of birth defects (n=9998) and non-malformed controls (n=4066) with dates of delivery between 1997 and 2004.
METHODS: Using paternal occupational histories reported by mothers via telephone interview, jobs were systematically classified into 63 groups based on shared exposure profiles within occupation and industry. Data were analysed using bayesian logistic regression with a hierarchical prior for dependent shrinkage to stabilise estimation with sparse data.
RESULTS: Several occupations were associated with an increased prevalence of various birth defect categories, including mathematical, physical and computer scientists; artists; photographers and photo processors; food service workers; landscapers and groundskeepers; hairdressers and cosmetologists; office and administrative support workers; sawmill workers; petroleum and gas workers; chemical workers; printers; material moving equipment operators; and motor vehicle operators.
CONCLUSIONS: Findings from this study might be used to identify specific occupations worthy of further investigation and to generate hypotheses about chemical or physical exposures common to such occupations.
Authors:
Tania A Desrosiers; Amy H Herring; Stuart K Shapira; Mariëtte Hooiveld; Tom J Luben; Michele L Herdt-Losavio; Shao Lin; Andrew F Olshan;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-07-09
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  69     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-09-27     Revised Date:  2014-04-07    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  534-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bayes Theorem
Case-Control Studies
Congenital Abnormalities / epidemiology,  etiology*
Fathers*
Humans
Infant, Newborn
Interviews as Topic
Logistic Models
Male
Occupational Exposure / adverse effects*
Occupations*
Prevalence
Risk Factors
Grant Support
ID/Acronym/Agency:
P30 ES010126/ES/NIEHS NIH HHS; P30ES10126/ES/NIEHS NIH HHS; R01 ES020619/ES/NIEHS NIH HHS; R24 HD050924/HD/NICHD NIH HHS; T32 ES007018/ES/NIEHS NIH HHS; U50CCU422096//PHS HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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