| Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study. | |
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MedLine Citation:
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PMID: 22782864 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ObjectivesSeveral epidemiological studies have suggested that certain paternal occupations may be associated with an increased prevalence of birth defects in offspring. Using data from the National Birth Defects Prevention Study, the authors investigated the association between paternal occupation and birth defects in a case-control study of cases comprising over 60 different types of birth defects (n=9998) and non-malformed controls (n=4066) with dates of delivery between 1997 and 2004.MethodsUsing paternal occupational histories reported by mothers via telephone interview, jobs were systematically classified into 63 groups based on shared exposure profiles within occupation and industry. Data were analysed using Bayesian logistic regression with a hierarchical prior for dependent shrinkage to stabilise estimation with sparse data.ResultsSeveral occupations were associated with an increased prevalence of various birth defect categories, including mathematical, physical and computer scientists; artists; photographers and photo processors; food service workers; landscapers and groundskeepers; hairdressers and cosmetologists; office and administrative support workers; sawmill workers; petroleum and gas workers; chemical workers; printers; material moving equipment operators; and motor vehicle operators.ConclusionsFindings from this study might be used to identify specific occupations worthy of further investigation and to generate hypotheses about chemical or physical exposures common to such occupations. |
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Authors:
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Tania A Desrosiers; Amy H Herring; Stuart K Shapira; Mariëtte Hooiveld; Tom J Luben; Michele L Herdt-Losavio; Shao Lin; Andrew F Olshan; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-9 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: - ISSN: 1470-7926 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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