Document Detail

Paternal and maternal birthweights and the risk of infant preterm birth.
MedLine Citation:
PMID:  18166307     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Increasing paternal birthweight has been associated with increased risk of fathering a preterm infant, causing speculation that a fetus programmed to grow rapidly can trigger preterm labor.
STUDY DESIGN: Pregnancies occurring from 1974-1989 among women themselves born in the Danish Perinatal Study (1959-1961) were identified through the Population Register; obstetric records were abstracted. Paternal birthweight was obtained by linking Personal Identification Numbers of the fathers to archived midwifery records.
RESULTS: Paternal birthweight was not associated with preterm infants overall. However, there was a significant interaction between paternal and maternal birthweights (P = .003). When the mother weighed less than 3 kg at birth, increasing paternal birthweight was associated with increased occurrence of preterm birth (P for trend = .02); paternal birthweight was unassociated with preterm birth for mothers weighing 3 kg or more at birth (P = .34).
CONCLUSION: When the mother was born small, increasing paternal birthweight was associated with increased risk of preterm birth, suggesting that a fetus growing faster than its mother can accommodate might trigger preterm birth.
Mark A Klebanoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-01-28     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58.e1-3     Citation Subset:  AIM; IM    
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
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MeSH Terms
Birth Weight / genetics*
Genetic Predisposition to Disease / epidemiology*
Genomic Imprinting / genetics*
Infant, Newborn
Infant, Premature
Premature Birth / genetics*
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Sex Factors
Grant Support
N01-HD-7-2902/HD/NICHD NIH HHS; NIH0010045861//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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