| Paternal dietary restriction affects progeny fat content in Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 22639405 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epidemiological data from human populations and few reports in rodents suggested that the paternal diet affects offspring adiposity and its related diseases. We tested whether this nongenetic and intergenerational inheritance depends on paternal treatment dose. Using the model organism Caenorhabditis elegans, males undergoing several dietary restriction regimes were crossed with ad libitum fed females. We found an inverted U-shaped relationship between the extent of paternal dietary restriction and the level of fat content of progeny. The relationship was evident in both sexes. Body proportions were not affected in offspring. Overall, our findings extent the concept of developmental and adaptive plasticity to include the extent of paternal food consumption in the origin of phenotypic alterations. © 2012 IUBMB IUBMB Life, 2012. |
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Authors:
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Claudia Miersch; Frank Döring |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-28 |
Journal Detail:
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Title: IUBMB life Volume: - ISSN: 1521-6551 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888706 Medline TA: IUBMB Life Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Kiel, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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