Document Detail

Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology.
MedLine Citation:
PMID:  21145051     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relationship between paternal body mass index (BMI), embryo development and pregnancy, and live birth outcomes after assisted reproductive technology (ART).
DESIGN: Retrospective analysis of ART cycles.
SETTING: Major assisted reproduction center.
PATIENT(S): Three hundred five couples undergoing ART in a private fertility clinic.
INTERVENTION(S): No intervention was undertaken in patients involved in this study.
MAIN OUTCOME MEASURE(S): Live birth outcomes and clinical pregnancy rates.
RESULT(S): No significant relationship between paternal BMI and early embryo development was found. However, increased paternal BMI was associated with decreased blastocyst development, clinical pregnancy rates and live birth outcomes.
CONCLUSION(S): To our knowledge, this is the first report linking increased paternal BMI and clinical pregnancy and live birth rates after ART treatment. Further work to elucidate the mechanisms involved is required.
Hassan W Bakos; Richard C Henshaw; Megan Mitchell; Michelle Lane
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-12-09
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-05-11     Revised Date:  2012-01-20    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1700-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Discipline of Obstetrics & Gynaecology, School of Paediatrics & Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, Australia.
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MeSH Terms
Blastocyst / physiology
Body Mass Index*
Embryonic Development / physiology*
Infertility / epidemiology,  therapy
Pregnancy Rate*
Reproductive Techniques, Assisted* / statistics & numerical data
Retrospective Studies
Semen Analysis
Comment In:
J Urol. 2012 Jan;187(1):245   [PMID:  22153469 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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