| Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. | |
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MedLine Citation:
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PMID: 22541433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In female mouse embryos, somatic cells undergo a random form of X chromosome inactivation (XCI), whereas extraembryonic trophoblast cells in the placenta undergo imprinted XCI, silencing exclusively the paternal X chromosome. Initiation of imprinted XCI requires a functional maternal allele of the X-linked gene Rnf12, which encodes the ubiquitin ligase Rnf12/RLIM. We find that knockout (KO) of Rnf12 in female mammary glands inhibits alveolar differentiation and milk production upon pregnancy, with alveolar cells that lack RLIM undergoing apoptosis as they begin to differentiate. Genetic analyses demonstrate that these functions are mediated primarily by the paternal Rnf12 allele due to nonrandom maternal XCI in mammary epithelial cells. These results identify paternal Rnf12/RLIM as a critical survival factor for milk-producing alveolar cells and, together with population models, reveal implications of transgenerational epigenetic inheritance. |
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Authors:
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Baowei Jiao; Hong Ma; Maxim N Shokhirev; Alexander Drung; Qin Yang; JongDae Shin; Shaolei Lu; Meg Byron; Sundeep Kalantry; Arthur M Mercurio; Jeanne B Lawrence; Alexander Hoffmann; Ingolf Bach |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Cell Volume: 149 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-30 Completed Date: 2012-06-22 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 630-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival* Epigenesis, Genetic Female Genomic Imprinting Male Mammary Glands, Animal / cytology*, physiology Mice Pregnancy Ubiquitin-Protein Ligases / genetics, metabolism* X Chromosome Inactivation |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA131158/CA/NCI NIH HHS; R01 CA131158-04/CA/NCI NIH HHS; R01CA131158/CA/NCI NIH HHS; R01CA89209/CA/NCI NIH HHS; R01GM053234/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 6.3.2.-/Rlim protein, mouse; EC 6.3.2.19/Ubiquitin-Protein Ligases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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