| Paternal contribution to small for gestational age babies: a multicenter prospective study. | |
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MedLine Citation:
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PMID: 21127471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our aims were to investigate whether men who fathered small for gestational age (SGA) infants themselves had lower birthweight, were more likely to be obese, have central adiposity and elevated blood pressure in adult life compared with men who fathered non-SGA infants. A total of 2,002 couples participating in the Screening for Pregnancy Endpoints (SCOPE) study were enrolled in early pregnancy and pregnancy outcome data collected prospectively. SGA was defined as birthweight <10th customized centile, obesity as BMI ≥30 kg/m(2), central adiposity as waist circumference >102 cm. Logistic regression was used to compare rates of obesity, and central adiposity between men who fathered SGA infants compared with those with non-SGA infants and the final model was adjusted for maternal and paternal confounders. The men who fathered an SGA infant (209 (10.4%)) themselves had lower mean birthweight (3,291 (530) g vs. 3,472 (584) g, P < 0.0001), were more likely to be obese (50 (24.8%) vs. 321 (18.3%), adjusted odds ratio (OR) 1.50, 95% confidence interval 1.05-2.16, adjusted for maternal and paternal factors) and to have central adiposity (52 (25.1%) vs. 341 (19.2%), adjusted OR 1.53, 95% confidence interval 1.06-2.20) compared with men who fathered a non-SGA infant. Elevated paternal blood pressure was not associated with SGA. In conclusion, we report a novel relationship between paternal obesity/central adiposity and birth of an SGA infant, which appears to be independent of maternal factors associated with fetal growth restriction. |
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Authors:
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Lesley M E McCowan; Robyn A North; Ee Min Kho; Michael A Black; Eliza H Y Chan; Gustaaf A Dekker; Lucilla Poston; Rennae S Taylor; Claire T Roberts |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-12-02 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-26 Completed Date: 2012-05-04 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1035-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand. l.mccowan@auckland.ac.nz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Australia / epidemiology Birth Weight Fathers / statistics & numerical data* Female Humans Hypertension / epidemiology* Infant, Newborn Infant, Small for Gestational Age* Logistic Models Male New Zealand / epidemiology Obesity / complications, epidemiology* Obesity, Abdominal / epidemiology Pregnancy Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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