Document Detail


Paternal contribution to small for gestational age babies: a multicenter prospective study.
MedLine Citation:
PMID:  21127471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our aims were to investigate whether men who fathered small for gestational age (SGA) infants themselves had lower birthweight, were more likely to be obese, have central adiposity and elevated blood pressure in adult life compared with men who fathered non-SGA infants. A total of 2,002 couples participating in the Screening for Pregnancy Endpoints (SCOPE) study were enrolled in early pregnancy and pregnancy outcome data collected prospectively. SGA was defined as birthweight <10th customized centile, obesity as BMI ≥30 kg/m(2), central adiposity as waist circumference >102 cm. Logistic regression was used to compare rates of obesity, and central adiposity between men who fathered SGA infants compared with those with non-SGA infants and the final model was adjusted for maternal and paternal confounders. The men who fathered an SGA infant (209 (10.4%)) themselves had lower mean birthweight (3,291 (530) g vs. 3,472 (584) g, P < 0.0001), were more likely to be obese (50 (24.8%) vs. 321 (18.3%), adjusted odds ratio (OR) 1.50, 95% confidence interval 1.05-2.16, adjusted for maternal and paternal factors) and to have central adiposity (52 (25.1%) vs. 341 (19.2%), adjusted OR 1.53, 95% confidence interval 1.06-2.20) compared with men who fathered a non-SGA infant. Elevated paternal blood pressure was not associated with SGA. In conclusion, we report a novel relationship between paternal obesity/central adiposity and birth of an SGA infant, which appears to be independent of maternal factors associated with fetal growth restriction.
Authors:
Lesley M E McCowan; Robyn A North; Ee Min Kho; Michael A Black; Eliza H Y Chan; Gustaaf A Dekker; Lucilla Poston; Rennae S Taylor; Claire T Roberts
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-12-02
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-26     Completed Date:  2012-05-04     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1035-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand. l.mccowan@auckland.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Australia / epidemiology
Birth Weight
Fathers / statistics & numerical data*
Female
Humans
Hypertension / epidemiology*
Infant, Newborn
Infant, Small for Gestational Age*
Logistic Models
Male
New Zealand / epidemiology
Obesity / complications,  epidemiology*
Obesity, Abdominal / epidemiology
Pregnancy
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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