Document Detail

Patent foramen ovale: thromboembolic structure or incidental finding?
MedLine Citation:
PMID:  21476380     Owner:  NLM     Status:  In-Process    
A patent foramen ovale (PFO) is identified in approximately 27% of healthy individuals undergoing routine autopsy and in 25% of the general population on transesophageal echocardiography (TEE). PFO generally considered benign, but has been associated with stroke, migraine and diving decompression sickness. We searched Pubmed for English language articles that examined the relationship of PFO to vascular events. PFOs are highly prevalent in patients with cryptogenic stroke and in patients with migraine, but the incidence of primary and recurrent stroke does not seem to be increased in patients with PFO. Consequently, neither anticoagulation nor antiplatelet drugs are recommended in asymptomatic patients lacking other indications for anticoagulation. In symptomatic patients with PFO, current guidelines consider antiplatelet medications as treatment of choice for cerebrovascular events. There is no strong evidence that supports routine closure of PFO in patients with stroke or migraine although some patients with combined characteristics of PFO might benefit from closure. In conclusion, this review suggests that PFO is not an established risk factor for stroke even in the young population with recurrent cryptogenic stroke.
Estelle Torbey; Paul D Thompson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Connecticut medicine     Volume:  75     ISSN:  0010-6178     ISO Abbreviation:  Conn Med     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-04-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372745     Medline TA:  Conn Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Staten Island Hospital, New York, USA.
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