Document Detail

Patent foramen ovale: a nonfunctional embryological remnant or a potential cause of significant pathology?
MedLine Citation:
PMID:  1622617     Owner:  NLM     Status:  MEDLINE    
A patent foramen ovale (PFO) is an embryological remnant found in 27% of adults. It is a potential right-to-left intracardiac shunt. Shunting may be the result of reversal in the interatrial pressure gradient or abnormal streaming of blood in the right atrium. The pathologic consequences of right-to-left shunting include hypoxemia and paradoxical embolism. PFO may exacerbate preexisting hypoxemia or be its primary cause. Paradoxical embolism through a PFO is well documented. Its role in cryptogenic stroke remains controversial. A PFO may be detected by both invasive and noninvasive techniques. Contrast transesophageal echocardiography with provocative maneuvers is the diagnostic method of choice allowing visualization of the shunt. Patients with cryptogenic stroke should be screened for a PFO. If detected, noninvasive studies for deep vein thrombosis are recommended. Treatment must be tailored to the presentation. Surgical or transcatheter closure is recommended for hypoxemia. Prevention of venous embolism (air or thrombus) with or without closure of the PFO is recommended for paradoxical embolism.
C Movsowitz; L A Podolsky; C B Meyerowitz; L E Jacobs; M N Kotler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  5     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-08-07     Completed Date:  1992-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-70     Citation Subset:  IM    
Division of Cardiovascular Disease, Albert Einstein Medical Center, Philadelphia, PA.
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MeSH Terms
Heart Septal Defects, Atrial* / complications,  diagnosis,  embryology*,  therapy
Pulmonary Circulation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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