Document Detail

Patent Ductus Arteriosus and Indomethacin Treatment as Independent Risk Factors for Plus Disease in Retinopathy of Prematurity.
MedLine Citation:
PMID:  23316949     Owner:  NLM     Status:  Publisher    
PURPOSE:To examine whether clinically significant patent ductus arteriosus (PDA) or indomethacin treatment are associated with plus disease or retinopathy of prematurity (ROP) requiring treatment. METHODS:Retrospective, cross-sectional study. Charts were reviewed for gestational age, birth weight, birth head circumference, birth length, maternal characteristics, gender, bronchopulmonary dysplasia, neurologic comorbidities, PDA and its treatments, gastrointestinal comorbidities, blood transfusions, and sepsis. Main outcome measures were increased rates of plus disease or ROP requiring treatment. RESULTS:A total of 450 premature infants screened for ROP in a mid-sized, urban neonatal intensive care unit were included. On univariate analysis, gestational age, birth weight, birth head circumference, birth length, bronchopulmonary dysplasia, neurologic comorbidities, PDA and its treatments, gastrointestinal comorbidities, and sepsis were significantly correlated to plus disease and ROP requiring treatment. PDA was significantly associated with bronchopulmonary dysplasia, neurologic comorbidities, sepsis, and blood transfusions (P < .0001). With type 3 multivariate analysis, only gestational age and bronchopulmonary dysplasia were independent risk factors for ROP. CONCLUSION:PDA and indomethacin were associated with plus disease and ROP requiring treatment on univariate analysis but this was not significant after adjusting for other risk factors. PDA was also strongly related to bronchopulmonary dysplasia and blood transfusions, which may explain its effect on ROP.
Irena Tsui; Edward Ebani; Jamie B Rosenberg; Juan Lin; Robert M Angert; Umar Mian
Related Documents :
9113589 - Developmental outcome of very low birth weight infants at four years of age as a functi...
7997499 - Apgar score and infant mortality in puerto rico.
550129 - Methadone exposure in utero: developmental status at one and two years of age.
3201969 - Vaginally born low-risk preterm infants: fetal acidosis and outcome at 6 years of age.
6685919 - Correlation of the one-minute apgar score and the ph value of umbilical arterial blood.
12029449 - Serial bronchoalveolar lavage of preterm infants is not associated with chest radiologi...
8235739 - Determinants of lactation performance across time in an urban population from mexico.
23935289 - Different fatty acid composition of serum phospholipids of small and appropriate for ge...
3165019 - The prevalence of cleft lip and plate in japanese.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  -     ISSN:  1938-2405     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Copyright Information:
Copyright 2013, SLACK Incorporated.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Visual Outcome and Changes in Corneal Endothelial Cell Density Following Aphakic Iris-Fixated Intrao...
Next Document:  Biologically Active Withanolides from Withania coagulans.