| Patency and blood flow in gas denucleated arterial prostheses. | |
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MedLine Citation:
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PMID: 8463350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biomaterials exposed to blood often fail due to thrombosis. Gas nuclei (air) in the material are thrombogenic and a potential cause of failure. The effects of gas nuclei on patency and blood flow were studied in 4 mm diameter arterial grafts (Gore ePTFE; Johnson and Johnson Vitagraft ePTFE; Bard ACG EXS) in the femoropopliteal position of dogs. Control and denucleated (air-free) grafts were implanted bilaterally. Grafts were denucleated by immersion in degassed saline and exposure to 4 torr vacuum and 3,000-20,000 psig pressure. Graft patency was determined at harvest in 46 dogs. Blood flow was measured with acoustic flow probes in eight dogs. Denucleated graft patency was 60% after 2 days of implant while control patency was 22% (P < .05). Measured blood flow was higher in denucleated grafts than in control grafts (P < .02) in 4 of 5 dogs which had significantly different flows. Patency and flow decreased to zero for both control and denucleated grafts over periods of up to 80 days. Air in the control grafts may have been absorbed within several days, leading to late similarity with the denucleated grafts. Thus, removing the air from 4 mm ePTFE grafts decreased acute thrombosis and increased the patency. |
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Authors:
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R D Vann; E F Ritter; M D Plunkett; C W Wyble; C V Bensen; W A Gerth; W J Barwick; B Klitzman |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 27 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-06 Completed Date: 1993-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 493-8 Citation Subset: IM; S |
Affiliation:
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F.G. Hall Hyperbaric Center, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials* Blood Vessel Prosthesis* Dogs Femoral Artery / physiology, surgery* Polyethylene Terephthalates Polytetrafluoroethylene Regional Blood Flow Time Factors Vascular Patency* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polyethylene Terephthalates; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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