Document Detail


Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy.
MedLine Citation:
PMID:  23035891     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
Authors:
Ann Pontén; Kristiina Aalto-Korte; Tove Agner; Klaus E Andersen; Ana M Giménez-Arnau; Margarida Gonçalo; An Goossens; Jeanne D Johansen; Christophe J Le Coz; Howard I Maibach; Thomas Rustemeyer; Ian R White; Magnus Bruze
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Contact dermatitis     Volume:  -     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden Finnish Institute of Occupational Health, Health and Work Ability, Control of Hypersensitivity Diseases, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark Department of Dermatology, Hospital del Mar and Univeristat Autònoma of Barcelona, 08003 Spain Department of Dermatology, Coimbra University Hospital, 3000-075 Coimbra, Portugal Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, 3000 Leuven, Belgium Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, DK-2900 Gentofte, Denmark Cabinet de Dermatologie and Laboratoire de Dermatochimie, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0989, USA Department of Dermatology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK.
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