Document Detail

Patch test reactions to metal salts in patients with oral mucosal lesions associated with amalgam restorations.
MedLine Citation:
PMID:  1451460     Owner:  NLM     Status:  MEDLINE    
Patch testing with various metal salts was performed in patients with oral mucosal lesions associated with amalgam restorations, by using polypropylene-coated aluminium discs. Positive reactions to mercuric chloride were obtained in 5/12 (42%) of these patients, but only in 1/11 patients (9%) with oral mucosal lesions unassociated with amalgam restorations and in 3/36 patients (8%) in a control group without mucosal lesions. The difference between the former group and the control patients is statistically significant (p less than 0.05). In addition, a positive test reaction to copper sulfate was obtained in 2 patients (16%) with amalgam-associated mucosal lesions and negative reactions to mercuric chloride. 2 of the 5 positive test reactions to mercuric chloride, in the patients with lichenoid mucosal lesions associated with amalgam, became lichenoid and persisted for at least 3 weeks. The patients with these reactions were also positive at a concentration of 0.05% mercuric chloride, but were negative to metallic mercury, in contrast to 2 other patients in the same group. This indicates the necessity of including mercuric chloride when patch testing such patients.
K Nordlind; S Lidén
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  27     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Dental Amalgam / adverse effects*
Dermatitis, Allergic Contact / diagnosis,  etiology
Drug Hypersensitivity / diagnosis*,  etiology
Mercuric Chloride / adverse effects
Metals / adverse effects*
Middle Aged
Mouth Diseases / chemically induced*
Mouth Mucosa / drug effects
Patch Tests / methods*
Reg. No./Substance:
0/Metals; 7487-94-7/Mercuric Chloride; 8049-85-2/Dental Amalgam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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