Document Detail


Pasty injectable biodegradable polymers derived from natural acids.
MedLine Citation:
PMID:  17595020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pasty biodegradable polymers that can be mixed with drugs at room temperature and injected to tissue as neat composition are advantageous as they allow simple preparation and delivery of drugs, particularly for heat sensitive drugs. A series of biodegradable pasty poly (ester-anhydride)s were prepared from alkanedicarboxylic acids and ricinoleic acid and its oligomers by transesterification-repolymerization method. The polymers were characterized by common spectroscopic, chromatography, and thermal methods. Polymers containing 70% ricinoleic acid and 30% linear dicarboxylic acids with 4-10 methylene groups were synthesized. The melting point of these poly (ester-anhydride)s increased as the number of methylenes in the alkanedicarboxylic acid increased. Use of short oligomers of ricinoleic acid instead of ricinoleic acid itself increased the melting point and decreased the softness of the resulting polymers. The polymers released model drugs for a few weeks while being degraded to their fatty acid counterparts. Copolymerization of alkanedicarboxylic acids with ricinoleic acid resulted in pasty biodegradable polymers useful as injectable carriers for drugs.
Authors:
Michal Y Krasko; Abraham J Domb
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  83     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1138-45     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007.
Affiliation:
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acids / chemistry*
Biocompatible Materials*
Hydrolysis
Magnetic Resonance Spectroscopy
Polymers / chemistry*
Spectrophotometry, Infrared
Chemical
Reg. No./Substance:
0/Acids; 0/Biocompatible Materials; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vivo stability and biocompatibility of implanted calcium alginate disks.
Next Document:  Quantification of carboxyl groups in carbodiimide cross-linked collagen sponges.