Document Detail

Past rifampicin dosing determines rifabutin resistance of Helicobacter pylori.
MedLine Citation:
PMID:  19142036     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recently, the number of Helicobacter pylori isolates showing antibiotic resistance has been increasing. Rifabutin (RFB) is one of the possible candidates for H. pylori eradication. In the present study, the RFB minimum inhibitory concentrations (MICs) and the resistance-determining genes to RFB (rpoB) were examined to clarify the relationship between drug MICs, rpoB mutations, and past history of rifampicin (RFP) treatment. METHODS: The MICs of RFB and rpoB mutations were examined for 48 strains with failure of H. pylori eradication in the University Hospital and 46 isolated from patients at a specialized hospital for chronic respiratory diseases without past H. pylori eradication. Past RFP treatment was also examined. RESULTS: Eight of 94 strains showed high RFB MICs and 6 of the 8 strains showed rpoB point mutations. Although no strains showed high RFB MICs among 48 strains from the patients in the University Hospital, all 7 strains isolated from patients with past RFP treatment showed high RFB MICs (>or=0.12 mg/l). CONCLUSION: Although RFB might be a potential candidate component of a new H. pylori eradication regimen following the first- or second-line failure, it should be used after examining a past history of RFP treatment.
Shoji Suzuki; Hidekazu Suzuki; Toshihiro Nishizawa; Fumihiko Kaneko; Sumire Ootani; Hiroe Muraoka; Yoshimasa Saito; Intetsu Kobayashi; Toshifumi Hibi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-14
Journal Detail:
Title:  Digestion     Volume:  79     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
DNA-Directed RNA Polymerases / genetics
Drug Resistance, Bacterial / genetics*
Endoscopy, Gastrointestinal
Helicobacter Infections / drug therapy,  microbiology*
Helicobacter pylori / drug effects*,  genetics,  isolation & purification
Microbial Sensitivity Tests
Middle Aged
Point Mutation
Polymerase Chain Reaction
Rifabutin / pharmacology*
Rifampin / administration & dosage,  pharmacology
Treatment Failure
Reg. No./Substance:
0/Anti-Bacterial Agents; 13292-46-1/Rifampin; 72559-06-9/Rifabutin; EC RNA Polymerases

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