Document Detail

Past occupational exposure to airborne manganese in a manganese alloy plant.
MedLine Citation:
PMID:  18464096     Owner:  NLM     Status:  MEDLINE    
A retrospective exposure assessment of a group of manganese (Mn) alloy workers was performed in conjunction with a 2004 follow-up study, 14 years after cessation of exposure, to evaluate the long-term effects of occupational Mn exposure on neurobehavioral functions. The ferro- and silico-Mn alloy plant opened in 1973 and closed in 1991. The airborne total Mn (TMn) exposures for job groupings were established using personal sampling data from a 1991 industrial hygiene survey. Historical short-term total dust (TDust) data were used to estimate past TDust exposure for job groupings and plant areas. Relationships between Mn content and TDust from the 1991 survey, supported by sparse historical data, were used to estimate TMn content in the historical TDust data. Results showed past personal TDust exposure levels much higher than those found in 1991. Changes in TDust levels and corresponding TMn levels were a function of changes in ventilation, work practices, and operations, not of product (ferro- or silico-Mn). Relationships between TMn and respirable Mn (RMn) from area sampling in 1991 were used to estimate RMn exposure for the job groups. Work histories for 112 workers were developed from payroll records, questionnaires, and interviews and combined with Mn exposure estimates to develop cumulative exposure indices (CEIs). The TMn CEI ranged from 0.27 mg/m(3)x years to 100.24 mg/m(3)x years, with an AM of 24.40 mg/m(3)x years and a GM of 14.06 mg/m(3)x years. The RMn CEI had an AM of 2.95 mg/m(3)x years and a GM of 1.78 mg/m(3)x years with a range of 0.05-12.03 mg/m(3)x years. Overall average TMn exposure intensity, the TMn CEI divided by time worked in years for each worker, had an AM of 1.6 mg Mn/m(3), a GM of 1.0 mg Mn/m(3), range 0.02-6.2 6 mg Mn/m(3). The results of the 2004 follow-up study showed several concentration-response relationships between TMn CEI and neurobehavioral outcomes, which suggest that increase in cumulative TMn exposure level has long-term consequences on the nervous system.
Mary Baldwin; Maryse Bouchard; Fabrice Larribe; Donna Mergler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental hygiene     Volume:  5     ISSN:  1545-9632     ISO Abbreviation:  J Occup Environ Hyg     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189458     Medline TA:  J Occup Environ Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-37     Citation Subset:  IM    
CINBIOSE, Université du Québec à Montréal, Québec, Canada.
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MeSH Terms
Air Pollutants, Occupational / analysis*
Analysis of Variance
Databases, Factual
Dust / analysis*
Environmental Monitoring / methods*
Longitudinal Studies
Manganese / analysis*
Nervous System Diseases / chemically induced
Occupational Exposure / analysis*,  classification
Occupations / classification
Retrospective Studies
Risk Assessment / methods
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Alloys; 0/Dust; 7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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