| Passive transfer of tuberculin sensitivity by tritiated thymidine-labeled lymphoid cells. | |
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MedLine Citation:
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PMID: 14478054 Owner: NLM Status: OLDMEDLINE |
Abstract/OtherAbstract:
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Passive transfer of tritiated thymidine-labeled BCG sensitized lymphoid cells into homologous guinea pigs resulted in positive tuberculin skin reactions 24 hours after testing with PPD. Labeled cells were found specifically attracted to these sites. Labeled non-sensitized lymphoid cells did not appear at PPD injection sites, nor did labeled sensitized cells accumulate in non-specific inflammatory lesions. The specifically reacting tritiated cells were small, medium, and large lymphocytes and stem or immature cells of the lymphoid series. In the homologous system employed, positive skin tests were either minimal or absent 3 days after transfusion of activated cells. The injected labeled sensitized cells were rapidly cleared from the circulating blood and lodged in the lungs, spleen, and lymph nodes. Upon application of specific antigen they reappeared at the skin test site at 6 hours and then increased in number for the next 18 hours. |
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Authors:
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J S NAJARIAN; J D FELDMAN |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 114 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1961 Nov |
Date Detail:
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Created Date: 1962-12-01 Completed Date: 1998-11-01 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: Not Available |
Other Details:
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Languages: eng Pagination: 779-90 Citation Subset: OM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Lymphoid Tissue
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transplantation* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1961, by The Rockefeller Institute Received Day: 20 Month: 7 Year: 1961 Print publication date: Day: 31 Month: 10 Year: 1961 Volume: 114 Issue: 5 First Page: 779 Last Page: 790 ID: 2180386 PubMed Id: 14478054 |
| PASSIVE TRANSFER OF TUBERCULIN SENSITIVITY BY TRITIATED THYMIDINE-LABELED LYMPHOID CELLS | |
| John S. Najarian | |
| Joseph D. Feldman | |
| From the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh |
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