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Passive transfer of tuberculin sensitivity by tritiated thymidine-labeled lymphoid cells.
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MedLine Citation:
PMID:  14478054     Owner:  NLM     Status:  OLDMEDLINE    
Passive transfer of tritiated thymidine-labeled BCG sensitized lymphoid cells into homologous guinea pigs resulted in positive tuberculin skin reactions 24 hours after testing with PPD. Labeled cells were found specifically attracted to these sites. Labeled non-sensitized lymphoid cells did not appear at PPD injection sites, nor did labeled sensitized cells accumulate in non-specific inflammatory lesions. The specifically reacting tritiated cells were small, medium, and large lymphocytes and stem or immature cells of the lymphoid series. In the homologous system employed, positive skin tests were either minimal or absent 3 days after transfusion of activated cells. The injected labeled sensitized cells were rapidly cleared from the circulating blood and lodged in the lungs, spleen, and lymph nodes. Upon application of specific antigen they reappeared at the skin test site at 6 hours and then increased in number for the next 18 hours.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  114     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1961 Nov 
Date Detail:
Created Date:  1962-12-01     Completed Date:  1998-11-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  779-90     Citation Subset:  OM    
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MeSH Terms
Lymphoid Tissue / transplantation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1961, by The Rockefeller Institute
Received Day: 20 Month: 7 Year: 1961
Print publication date: Day: 31 Month: 10 Year: 1961
Volume: 114 Issue: 5
First Page: 779 Last Page: 790
ID: 2180386
PubMed Id: 14478054

John S. Najarian
Joseph D. Feldman
From the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh

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