Document Detail


Passive transfer of methacholine sensitivity from man to monkey.
MedLine Citation:
PMID:  3819225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model of human allergic disease, in which nonhuman primates were infused with serum from allergic humans and challenged with appropriate antigen, was used to determine whether the animals also develop hyperreactive airways characteristic of asthma. Anesthetized monkeys were insufflated with increasing concentrations of methacholine aerosol, and changes in pulmonary function were measured. Airway reactivity as assessed by the dose of methacholine aerosol culminating in apnea was determined after infusion of serum from allergic or nonallergic humans or with heated allergic serum. A comparison of the results indicated that only infusion of unheated serum from allergic humans resulted in an increase in airway reactivity to aerosolized methacholine. These results suggest that a factor in the serum of allergic humans may play a role in the hyperreactivity of airways characteristic of asthma.
Authors:
J N Fink; D P Schlueter; J J Barboriak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  79     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-04-16     Completed Date:  1987-04-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apnea / immunology
Drug Hypersensitivity / etiology,  transmission*
Humans
Immunization, Passive*
Lung / physiopathology
Macaca
Methacholine Compounds / adverse effects*
Grant Support
ID/Acronym/Agency:
AI 09694/AI/NIAID NIH HHS; AI 19104/AI/NIAID NIH HHS; HL 29319/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Methacholine Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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