Document Detail

Passive transfer of antibodies of maternal origin from blood to cerebrospinal fluid in infants.
MedLine Citation:
PMID:  47079     Owner:  NLM     Status:  MEDLINE    
The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (c.s.f.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.f. of infants. These observations suggest that an important source of immunoglobulins in c.s.f. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with c.s.f.
J D Thorley; J M Kaplan; R K Holmes; G H McCracken; J P Sanford
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  651-3     Citation Subset:  AIM; IM    
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MeSH Terms
Cerebrospinal Fluid / analysis*
Diphtheria / immunology
Diphtheria Antitoxin / isolation & purification*
Hemagglutination Tests
Immunity, Maternally-Acquired*
Immunization, Passive
Immunoglobulin M / cerebrospinal fluid
Immunoglobulins / isolation & purification
Infant, Newborn
Maternal-Fetal Exchange*
Neurosyphilis / cerebrospinal fluid,  diagnosis,  immunology
Syphilis Serodiagnosis
Tetanus / immunology
Tetanus Antitoxin / isolation & purification*
Reg. No./Substance:
0/Diphtheria Antitoxin; 0/Immunoglobulin M; 0/Immunoglobulins; 0/Tetanus Antitoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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