| Passive transfer of antibodies of maternal origin from blood to cerebrospinal fluid in infants. | |
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MedLine Citation:
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PMID: 47079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (c.s.f.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.f. of infants. These observations suggest that an important source of immunoglobulins in c.s.f. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with c.s.f. |
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Authors:
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J D Thorley; J M Kaplan; R K Holmes; G H McCracken; J P Sanford |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1975 Mar |
Date Detail:
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Created Date: 1975-06-02 Completed Date: 1975-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 651-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebrospinal Fluid
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analysis* Diphtheria / immunology Diphtheria Antitoxin / isolation & purification* Female Hemagglutination Tests Humans Immunity, Maternally-Acquired* Immunization, Passive Immunoglobulin M / cerebrospinal fluid Immunoglobulins / isolation & purification Infant, Newborn Maternal-Fetal Exchange* Neurosyphilis / cerebrospinal fluid, diagnosis, immunology Pregnancy Syphilis Serodiagnosis Tetanus / immunology Tetanus Antitoxin / isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Diphtheria Antitoxin; 0/Immunoglobulin M; 0/Immunoglobulins; 0/Tetanus Antitoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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