| Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. | |
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MedLine Citation:
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PMID: 17526865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors investigated whether polymorphisms in two maternal metabolic genes, cytochrome P-450 1A1 (CYP1A1) MspI and epoxide hydrolase 1 (EPHX1) Tyr113His, affect the association of maternal passive smoking with infant birth weight. The study was conducted in a cohort of 1,388 newly married mothers of liveborn singletons who worked in textile mills in Anqing, China, from 1996 to 2000. Multiple linear regression models were used to estimate the associations of passive smoking and genetic susceptibility with birth weight, with adjustment for important potential confounders. In the passive smoking group, there was a remarkable decrease in birth weight with the C/C6235 genotype (156.3 g, 95% confidence interval (CI): -283.6, -29.0) for CYP1A1 MspI and with Tyr/His113 (93.8 g, 95% CI: -188.6, -1.1) as compared with His/His113 (244.6 g, 95% CI: -491.0, -1.9) for EPHX1. When results were stratified by maternal genotype, passive smoking conferred a significantly negative effect in the EPHX1 Tyr/His113 group (103.5 g, 95% CI: -205.8, -9.2) and in the His/His113 group (687.3 g, 95% CI: -748.3, -178.3). The data further showed that there was a significant interaction between maternal passive smoking and maternal EPHX1 genotype for birth weight. The authors conclude that the CYP1A1 MspI and EPHX1 genotypes modified the association between maternal passive smoking and infant birth weight in this study, which is suggestive of possible gene-environment interaction. |
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Authors:
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Ting Wu; Yonghua Hu; Changzhong Chen; Fan Yang; Zhiping Li; Zhian Fang; Lihua Wang; Dafang Chen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-05-25 |
Journal Detail:
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Title: American journal of epidemiology Volume: 166 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-13 Completed Date: 2007-08-30 Revised Date: 2010-05-21 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 313-22 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China, and Brigham and Women's Hospital, Boston, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight* China / epidemiology Cytochrome P-450 CYP1A1 / genetics* Epoxide Hydrolases / genetics* Female Genetic Predisposition to Disease Genotype Humans Polymorphism, Genetic* Prospective Studies Risk Factors Tobacco Smoke Pollution / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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ES-00002/ES/NIEHS NIH HHS; ES06198/ES/NIEHS NIH HHS; ES08957/ES/NIEHS NIH HHS; ES11682/ES/NIEHS NIH HHS; ES8337/ES/NIEHS NIH HHS; HD32505/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tobacco Smoke Pollution; EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 3.3.2.-/Epoxide Hydrolases; EC 3.3.2.9/EPHX1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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