| Passive rotation-induced theta rhythm and orientation homeostasis response. | |
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MedLine Citation:
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PMID: 20034015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rhythmic oscillatory activities at the theta frequency (3-12 Hz) have long attracted attention, as they have been implicated in diverse brain functions. There are two kinds of hippocampal theta rhythms: Type 1 is an atropine-resistant noncholinergic theta rhythm, and Type 2 is an atropine-sensitive cholinergic theta rhythm. However, it has not yet been determined whether the theta rhythm generated during passive whole-body rotation is of Type 1 or 2. To clarify this issue, we investigated passive whole-body rotation-induced theta rhythm using C57BL/6J normal and atropine-treated mice. The results demonstrated that atropine [50 mg/kg, intraperitoneally (i.p.)], a cholinergic antagonist, abolished the theta rhythm generated during passive whole-body rotation. Therefore, the passive whole-body rotation-induced theta rhythm is an atropine-sensitive Type 2 theta rhythm. In addition, we found that blocking cholinergic receptors using atropine resulted in the loss of the orientation homeostasis response, which is a circling behavior in the direction opposite to that of the rotating circular treadmill that is generated to maintain a constant orientation. These results suggest that atropine-sensitive Type 2 theta rhythm can be generated by a passive rotation-induced vestibular sensory signal and may be necessary for spatial orientation homeostasis response behavior. |
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Authors:
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Jonghan Shin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Synapse (New York, N.Y.) Volume: 64 ISSN: 1098-2396 ISO Abbreviation: Synapse Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-16 Completed Date: 2010-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806914 Medline TA: Synapse Country: United States |
Other Details:
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Languages: eng Pagination: 409-15 Citation Subset: IM |
Affiliation:
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Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon 405-760, Republic of Korea. jhshin@gachon.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Darkness Electrodes, Implanted Electroencephalography Hippocampus / drug effects, physiology* Homeostasis / drug effects, physiology* Male Mice Mice, Inbred C57BL Motor Activity / drug effects, physiology Movement / drug effects, physiology* Muscarinic Antagonists / pharmacology Orientation / physiology* Rotation* Theta Rhythm* / drug effects Visual Perception / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Muscarinic Antagonists; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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