Document Detail

Passive mechanical properties of cardiac tissues in heart hypertrophy during pregnancy.
MedLine Citation:
PMID:  19565322     Owner:  NLM     Status:  MEDLINE    
We evaluated changes in passive mechanical properties in cardiac tissues during rat pregnancy. Left and right ventricular free walls were dissected from hearts of nonpregnant, late-pregnant, and postpartum rats. Mechanical experiments in ventricular strips were done by stretch-release cycles using a step motor. The results show that during pregnancy, there is cardiac hypertrophy associated with (1) an increase in myocyte size, particularly of augmented myocyte length, (2) a decrease in passive tension developed by the myocardial walls, and (3) a decrease in both elastic modulus and hysteresis. All changes observed during rat pregnancy were reversed during postpartum. In conclusion, a heart with less ventricular rigidity could contribute to facilitating the ventricular filling in conditions of a greater circulating volume characteristic of pregnancy.
Adolfo Virgen-Ortiz; J L Marin; A Elizalde; E Castro; E Stefani; L Toro; J Muñiz
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-30
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  59     ISSN:  1880-6546     ISO Abbreviation:  J Physiol Sci     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-19     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Departamento de Ciencias Químico-Biológicas, Unidad Regional Sur Campus Navojoa, Universidad de Sonora, Blvd. Lázaro Cárdenas No. 100, Colonia Francisco Villa, 85880, Navojoa, Sonora, Mexico.
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MeSH Terms
Cardiomegaly / pathology*,  physiopathology*
Disease Models, Animal
Elasticity / physiology
Heart / physiopathology*
Myocardial Contraction / physiology
Myocardium / pathology*
Myocytes, Cardiac / pathology
Organ Size / physiology
Pregnancy Complications, Cardiovascular / pathology*,  physiopathology*
Pregnancy, Animal / physiology*
Rats, Sprague-Dawley

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