Document Detail


Passive leg movement-induced hyperemia with a spinal cord lesion: Evidence of preserved vascular function.
MedLine Citation:
PMID:  24119139     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A spinal cord injury (SCI) clearly results in greater cardiovascular risk, however, accompanying changes in peripheral vascular structure below the lesion, mean the real impact of a SCI on vascular function is unclear. Therefore, utilizing passive leg movement-induced (PLM) hyperemia, an index of nitric oxide (NO)-dependent vascular function, and the central hemodynamic response to this intervention, we studied 8 individuals with a SCI, and 8 age-matched controls (CTRL). Specifically, we assessed heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), leg blood flow (LBF), and thigh composition. In CTRL, passive movement, transiently decreased MAP, and increased HR and CO from baseline by 2.5±1 mmHg, 7±2 bpm, and 0.5±0.1 l/min respectively. In SCI, HR and CO responses were unidentifiable. LBF increased to a greater extent in CTRL (515±41 ∆ml/min) compared to SCI, (126±25 ∆ml/min) (p<0.05). There was a strong relationship between ∆LBF and thigh muscle volume (r = 0.95). After normalizing ∆LBF for this strong relationship (∆LBF/muscle volume), there was evidence of preserved vascular function in SCI (CTRL: 120±9; SCI 104±11 ml/min/l). A comparison of ∆LBF in the passively moved and stationary leg, to partition the contribution of the blood flow response, implied that 35% of the hyperemia resulted from cardioacceleration in the CTRL, whereas all the hyperemia appeared peripheral in origin in the SCI. Thus, utilizing PLM-induced hyperemia as marker of vascular function, it is evident that peripheral vascular impairment is not an obligatory accompaniment to a SCI. This article is protected by copyright. All rights reserved.
Authors:
Massimo Venturelli; M Amann; G Layec; J McDaniel; J D Trinity; A S Fjeldstad; S J Ives; G Yonnet; R S Richardson
Related Documents :
10511659 - Identification of cardiac masses and abnormal blood flow patterns with harmonic power d...
11337679 - Assessment of ventricular filling volumes with an automated color doppler method: valid...
12199419 - Doppler angle estimation of pulsatile flows using ar modeling.
141589 - The pulsed doppler ultrasound flowmeter: experimental evaluation of velocity accuracy a...
25327449 - Simultaneous estimation of bidirectional particle flow and relative flux using music-oc...
3196819 - Dual-fiber laser doppler velocimeter and its application to the measurements of coronar...
1782609 - Correlation between cerebral blood flow, somatosensory evoked potentials, ct scan grade...
22187459 - Review of flow rate estimates of the deepwater horizon oil spill.
10518689 - Rheological characterization of pharmaceutical powders using tap testing, shear cell an...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-1
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differences in differential gene expression between young and mature Arabidopsis C58 tumours.
Next Document:  Deprivation and access to treatment for colorectal cancer in Southeast Scotland 2003 - 2009.