Document Detail

Passive immunity of premature infants against measles during early infancy.
MedLine Citation:
PMID:  10591429     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the presence of transferred measles antibodies and seronegativity rates during early infancy in premature newborns whose mothers had infection-induced immunity. The premature group was composed of 22 and 35 newborns of gestational ages < 32 wk and > 32 wk, respectively, and the control group consisted of 28 term newborns. Enzyme-linked immunosorbent assay (ELISA) was used for the qualitative detection of IgG antibodies to measles virus. Mean cord blood relative values were significantly lower in both premature groups, < or = 32 wk (p < 0.0001) and > 32 wk (p < 0.001), when compared with term infants. No seronegative infant was found in the premature group at 2 mo of age. At 4 mo, the seronegativity rate was 27% for premature infants < or = 32 wk and 35% for those > 32 wk. At 6 mo, seronegativity increased to 86% and 74% for premature infants born at gestational ages < or = 32 wk and > 32 wk, respectively. Forty-six percent of the term infants became seronegative at that age. The differences between term infants and those in the two premature groups were statistically significant (p < 0.05 and p < 0.005). Premature infants, regardless of their prematurity degree, were thought to be more susceptible to measles infection than term ones at the age of 6 mo. Policies for their protection from measles infection are still to be investigated.
S Ozbek; M Vural; Y Tastan; I Kahraman; Y Perk; O Ilter
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  88     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1254-7     Citation Subset:  IM    
Department of Pediatrics, Cerrahpaşa University Hospital, Istanbul, Turkey.
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MeSH Terms
Antibodies, Viral / analysis*
Enzyme-Linked Immunosorbent Assay
Fetal Blood / immunology
Gestational Age
Immunity, Maternally-Acquired / immunology*
Infant, Newborn
Infant, Premature / immunology*
Longitudinal Studies
Measles / immunology*
Measles virus / immunology*
Prospective Studies
Reference Values
Regression Analysis
Risk Assessment
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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