| Passive exposure of adult cats to bandlimited tone pip ensembles or noise leads to long-term response suppression in auditory cortex. | |
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MedLine Citation:
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PMID: 21316436 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have recently demonstrated that persistent, passive exposure of adult cats to bandlimited tone pip ensembles at moderate intensities (˜70 dB SPL) leads to a long-term suppression of neural activity in auditory cortex, in the absence of hearing loss. With wideband ensembles (4-20 kHz), the suppression is limited to the exposure frequency range; with narrowband ensembles (2-4 kHz, or third-octave bands centered at 4 and 16 kHz), suppression occurs not only within but also well beyond the exposure range, at least in primary auditory cortex (AI). (In secondary cortex (AII) suppression remains limited mostly to the exposure range even for narrowband ensembles.) We report here on two additional experiments. First, we demonstrate suppression in both AI and AII upon exposure to 4-20 kHz bandlimited noise, thus generalizing our previous results obtained with tonal ensembles. However, we found a somewhat different suppression pattern with noise. Whereas 4-20 kHz tone exposure produced relatively uniform suppression over the 4-20 kHz range, save for a small local minimum at ˜10 kHz, 4-20 kHz noise produced maximal suppression over ˜4-10 kHz, which then progressively weakened with frequency up to 20 kHz. Second, we outline the time course of the emergence of response suppression in AI, using the above-mentioned pair of third-octave bands as the exposure stimulus. Suppression emerged relatively rapidly, within a week of exposure onset, and was initially confined to frequencies close to the 4 and 16 kHz stimulus bands. Over the course of several more weeks, the suppression broadened to cover the entire 4-16 kHz range. We discuss these new findings with reference to the putative mechanisms underlying exposure-induced auditory cortical plasticity. |
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Authors:
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Martin Pienkowski; Raymundo Munguia; Jos J Eggermont |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-10 |
Journal Detail:
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Title: Hearing research Volume: - ISSN: 1878-5891 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900445 Medline TA: Hear Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Departments of Physiology and Pharmacology, and Psychology, University of Calgary, Calgary, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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