| Passive expiratory flow-volume recordings in immature newborn rabbits. Effect of surfactant replacement on the time constant of the respiratory system. | |
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MedLine Citation:
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PMID: 2359891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immature newborn rabbits with a gestational age of 27 days were paralyzed and kept in body plethysmographs. They were ventilated for 10 min with a tidal volume of approximately 10 ml/kg, with or without previous surfactant treatment via the airways. Tidal volumes and flow were recorded with a pneumotachograph connected to the body plethysmograph, and the expiratory time constant of the respiratory system (trs) was determined from flow-volume diagrams. The values of trs after 10 min were significantly higher in surfactant-treated animals than in controls (50 +/- 7 vs. 23 +/- 4 ms; p less than 0.002), indicating stabilization of the alveoli. There was also a close correlation between trs and the compliance values calculated from tidal volumes and ventilator pressure (r = 0.80; p less than 0.001), as well as between trs and the alveolar volume density in histological lung sections, determined by automated image analysis (r = 0.71; p less than 0.001). |
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Authors:
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G Noack; T Curstedt; G Grossmann; R Nilsson; B Robertson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 57 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 1990 |
Date Detail:
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Created Date: 1990-08-01 Completed Date: 1990-08-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
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Department of Pediatric Anesthesiology, St. Göran's Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Gestational Age Lung / cytology, drug effects Lung Compliance / drug effects Lung Volume Measurements Pulmonary Surfactants / pharmacology* Rabbits Respiratory Mechanics / drug effects* Tidal Volume / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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