| Passive cutaneous anaphylaxis in guinea pigs elicited by gastric absorption of dextran induced by acetylsalicylic acid. | |
| | |
MedLine Citation:
|
PMID: 965109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Passive cutaneous anaphylaxis (PCA) was elicited in guinea pigs sensitized with rabbit antidextran by the absorption of dextran macromolecules from the stomach induced by intragastric acetylsalicylic acid. The gastric contents had a pH sufficiently low to maintain the acid mainly in the unionized form since it is the latter which alters gastric permeability. The acid concentration required to induce PCA was below that which caused mucosal cell loss or bleeding. The maximal molecular weight of the absorbed dextran was approximately 25,000. Dextran was chosen as antigen because of its well-characterized physical and immunological properties. It is suggested that ingestion of acetylsalicylic acid may contribute to sensitization and allergic reactions to antigenic food materials by facilitating their absorption from the stomach. |
| | |
Authors:
|
G Flemström; N V Marsden; W Richter |
Related Documents
:
|
7562119 - In situ intestinal absorption of 2-o-alpha-d-glucopyranosyl-l-ascorbic acid in guinea p... 4293959 - The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas. 6746609 - Purification and characterization of hyaluronic acid from the horny layer of guinea pigs. 18378229 - Comparative efficacy of topical antihistamines in an animal model of early phase allerg... 8277249 - Biological activities of lipoteichoic acid and peptidoglycan-teichoic acid of bacillus ... 8462289 - Measurement of skin-fold thickness in the guinea pig. assessment of edema-inducing capa... 3774259 - Enterohepatic circulation and distribution of 131i-6 beta-iodomethyl-19-norcholesterol ... 16622829 - Comparative proteomics of glycosomes from bloodstream form and procyclic culture form t... 7773619 - The specific inhibition of crystal growth of monohydrogen potassium l-tartrate by d-cat... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International archives of allergy and applied immunology Volume: 51 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1976 |
Date Detail:
|
Created Date: 1976-11-21 Completed Date: 1976-11-21 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 627-36 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Animals Aspirin / pharmacology* Dextrans / metabolism* Female Gastric Mucosa / metabolism* Guinea Pigs Male Molecular Weight Passive Cutaneous Anaphylaxis* |
| Chemical | |
Reg. No./Substance:
|
50-78-2/Aspirin; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phytohaemagglutinin (PHA) skin test in predicting prognosis in cancer patients.
Next Document: Computerised assessment of cardiac pacemaker performance.