Document Detail

Passive and active maternal smoking as measured by serum cotinine: the effect on birthweight.
MedLine Citation:
PMID:  7892926     Owner:  NLM     Status:  MEDLINE    
To determine how maternal exposure to environmental tobacco smoke affects birthweight, maternal sera obtained from 3529 pregnant women around 27 weeks gestation were analyzed for cotinine, a metabolite of nicotine. Based on cotinine levels, nonsmokers were divided into those exposed to environmental tobacco smoke (2-10 ng/mL) and those unexposed (< 2 ng/mL), and smokers were divided into tertiles. Compared with unexposed nonsmokers' infants, infants of exposed nonsmokers averaged 45 g less (P = .28) after adjustment for confounders, and smokers' infants averaged 78, 191, and 233 g less for the first, second, and third cotinine tertiles, respectively. Birthweight decreased 1 g for every nanogram per milliliter of cotinine increase (P < .001).
B Eskenazi; A W Prehn; R E Christianson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of public health     Volume:  85     ISSN:  0090-0036     ISO Abbreviation:  Am J Public Health     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-19     Completed Date:  1995-04-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  AIM; IM    
Maternal and Child Health and Epidemiology Programs, School of Public Health, University of California-Berkeley 94720.
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MeSH Terms
Analysis of Variance
Birth Weight*
Chi-Square Distribution
Cotinine / blood*
Dose-Response Relationship, Drug
Infant, Low Birth Weight
Infant, Newborn
Multivariate Analysis
Pregnancy Trimester, Third / blood
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution; 486-56-6/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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