Document Detail


Passive and active exercises increase cerebral blood flow velocity in young, healthy individuals.
MedLine Citation:
PMID:  9862534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unlike the well-examined cardiovascular changes during movement stimuli, changes of cerebral hemodynamics and cerebral metabolism in physical exercises have, as yet, rarely been studied. Our objective was to investigate whether there are changes in cerebral hemodynamics and cerebral metabolism caused by active and passive movement stimuli. Response to repetitive active and passive movement stimuli was studied in 14 volunteers (8 females, 6 males; mean age, 35.2+/-8 yr). Each volunteer was subjected to four measurement series while performing a defined active and passive exercise program of the right upper or right lower limb. Measurement series were designed according to Aaslid's "evoked flow test"; exercises were performed for 20 s, followed by a rest of 20 s. This sequence was repeated 10 times in each series. As a measure of cerebral hemodynamics mean and peak blood flow velocity of the middle cerebral artery were recorded by transcranial Doppler sonography (Multidop-X-DWL). In addition, cerebral metabolism was quantified in a subsample by means of oxygenic cytochrome aa3 (respiratory chain enzyme), cerebral oxygen saturation using near infrared spectroscopy (Critikon). As well, noninvasive blood pressure (Penaz method) and expiratory pCO2 were measured. Compared with resting measures, an increase in mean cerebral blood flow velocity of the middle cerebral artery of 3.8% (P = 0.003, paired t test) was observed after active exercises of the right lower limb and 3.5% after active exercises of the right upper limb. Respective changes were 3.4% (P = 0.004) for passive exercises of the lower limb and 4.6% (P = 0.007) for passive exercises of the right upper limb. Peak cerebral blood flow velocity of the middle cerebral artery showed an even more pronounced increase during passive and active exercises in all cases, with values of between 12.2% (P < 0.001) and 13.6% (P < 0.001). Significant increases (1.5-3%) of cytochrome aa3 and cerebral oxygen saturation were observed during active and passive exercises. These studies show that active as well as passive exercises are followed by an increase of cerebral blood flow velocity. We attribute the increase of cerebral hemodynamic and cerebral metabolism to cerebral activation and autoregulative mechanisms.
Authors:
T J Doering; K L Resch; B Steuernagel; J Brix; B Schneider; G C Fischer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  77     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-01-05     Completed Date:  1999-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  490-3     Citation Subset:  AIM; IM    
Affiliation:
Department Clinic for Studies OE 5440/Reha, Medical University Hannover, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / physiology*
Blood Pressure / physiology
Brain / metabolism
Carbon Dioxide / physiology
Cerebral Arteries / physiology,  ultrasonography
Cerebrovascular Circulation*
Electron Transport Complex IV / metabolism
Exercise Therapy / methods*
Female
Humans
Male
Oxygen / blood
Ultrasonography, Doppler, Transcranial
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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