Document Detail


Passage of carbohydrate into the colon. Direct measurements in humans.
MedLine Citation:
PMID:  6873605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To quantify passage of unabsorbed dietary starch into the colon, 7 healthy volunteers had a multilumen tube positioned close to the ileocecal junction. Marker solution was perfused slowly, 20-40 cm above an aspiration site, to estimate, by marker dilution, flow through the ileum. On consecutive days, subjects ate liquidized meals containing 20 or 60 g starch; ileal aspirates were analyzed for starch and glucose for 5-6 h fasting and 4-7 h postprandially. Volume and carbohydrate concentrations were used to derive total carbohydrate traversing the ileum. In different subjects, unabsorbed carbohydrate was 453-4023 mg (2.3%-20.1%, mean 9.3%) for the smaller meal and 1332-6352 mg (2.2%-10.4%, mean 6.0%) for the larger. In 4 volunteers, hydrogen breath tests were performed on separate occasions after sucrose (50 g), lactulose (26 g), and the 20-g meal. Lactulose increased hydrogen excretion; sucrose and the test meal did not. We conclude that 2%-20% of dietary starch escapes absorption in the small bowel, confirming others' results using breath tests alone. Breath tests, though more convenient than intubation studies, may be a less sensitive index of starch malabsorption.
Authors:
A M Stephen; A C Haddad; S F Phillips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  85     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  589-95     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Transport
Breath Tests
Colon / physiology*
Dietary Carbohydrates / metabolism*
Female
Gastrointestinal Motility
Hexosamines / metabolism
Humans
Hydrogen
Ileocecal Valve / physiology
Ileum / physiology
Intestinal Absorption
Lactulose / metabolism
Male
Middle Aged
Mucus / physiology
Starch / metabolism*
Sucrose / metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
RR00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Hexosamines; 1333-74-0/Hydrogen; 4618-18-2/Lactulose; 57-50-1/Sucrose; 9005-25-8/Starch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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