Document Detail

Parvovirus diversity and DNA damage responses.
MedLine Citation:
PMID:  23293137     Owner:  NLM     Status:  MEDLINE    
Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an evolutionary adaptation of rolling-circle synthesis in which the hairpins create duplex replication origins, prime complementary strand synthesis, and act as hinges to reverse the direction of the unidirectional cellular fork. Genomes are packaged vectorially into small, rugged protein capsids ~260 Å in diameter, which mediate their delivery directly into the cell nucleus, where they await their host cell's entry into S phase under its own cell cycle control. Here we focus on genus-specific variations in genome structure and replication, and review host cell responses that modulate the nuclear environment.
Susan F Cotmore; Peter Tattersall
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-02-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  5     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-08-01     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
DNA Damage*
DNA Replication
DNA, Viral / chemistry
Genetic Variation
Genome, Viral
Parvovirus / genetics*,  pathogenicity,  physiology
Virus Replication / genetics,  physiology
Grant Support
Reg. No./Substance:
0/DNA, Viral

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