Document Detail

Parvovirus B19 infection in pregnancy studied by maternal viral load and immune responses.
MedLine Citation:
PMID:  17003557     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Facilitate risk assessment of vital complications in fetuses of pregnancies affected by acute parvovirus B19 (B19V) infection. DESIGN: Study of the natural course of maternal B19V infection in four cases, from early pregnancy on. SETTING: University Medical Center in the Netherlands. POPULATION: Pregnant mothers attending obstetric services. METHODS: Serial measurements of the maternal and fetal or neonatal viral load and antibody responses. MAIN OUTCOME MEASURES: Maternal and fetal/neonatal serum B19V viral DNA load and specific IgM and IgG antibodies in maternal serum. RESULTS: Peak viral load levels occurred within 1 week after maternal infection and peak IgM levels were observed 1 week after the peak viral load levels. Approximation of IgG and IgM ratios usually took place 4 weeks after infection. Vertical transmission occurred 1-3 weeks after maternal infection, suggesting that fetal infection occurs during the maternal peak viral load. CONCLUSIONS: Maternal B19V DNA load levels and IgM responses are useful to estimate the risk of parvovirus B19-associated fetal complications. The maternal peak viral load directly precedes the onset of fetal infection and may be used to indicate the stage of intrauterine B19V infection.
Timo R de Haan; Matthias F C Beersma; Eric C J Claas; Dick Oepkes; Aloys C M Kroes; Frans J Walther
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-09-22
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  22     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2007  
Date Detail:
Created Date:  2006-12-28     Completed Date:  2007-02-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
DNA, Viral / blood
Fetal Blood / immunology,  virology
Immunoglobulin G / blood
Immunoglobulin M / blood
Infectious Disease Transmission, Vertical
Parvoviridae Infections / immunology*,  transmission,  virology
Parvovirus B19, Human / immunology*
Pregnancy Complications, Infectious / immunology*,  virology
Viral Load
Reg. No./Substance:
0/DNA, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

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