Document Detail

Parvovirus B19 in pregnancy: prenatal diagnosis and management of fetal complications.
MedLine Citation:
PMID:  22249146     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: Parvovirus B19 infection is often considered a mild and self-limiting disease of minor clinical importance. This review aims to raise awareness of recently discovered potentially devastating consequences of this infection in pregnancy, and provides updated guidelines on diagnosis and management. RECENT FINDINGS: In contrast to previous beliefs, parvovirus B19 infection during any stage of pregnancy may not only cause fetal death, but may also result in severe and irreversible neurological sequelae in survivors. Improved diagnostic techniques allow more reliable and earlier diagnosis of fetal disease. SUMMARY: Clinicians need to be aware of the risk of adverse outcome of parvovirus B19 infection in pregnancy, and sometimes the long interval between exposure and fetal symptoms. Accurate diagnosis using PCR and weekly ultrasound checks ups with Doppler measurement of middle cerebral artery flow velocity up to 20 weeks postexposure may improve detection of fetal disease. More timely treatment likely results in improved outcome.
Anneke C Dijkmans; Eveline P de Jong; Ben A C Dijkmans; Enrico Lopriore; Ann Vossen; Frans J Walther; Dick Oepkes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-13
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  -     ISSN:  1473-656X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Medical Microbiology, Leiden University Medical Centre, Leiden bDepartment of Medical Microbiology, HAGA Hospital, The Hague cDepartment of Paediatrics, Juliana Children's Hospital, HAGA Hospital, The Hague dDepartment of Rheumatology, VU Amsterdam, Amsterdam eDivision of Neonatology, Department of Paediatrics fDivision of Fetal Medicine, Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands.
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