Document Detail


Partitioning the heart: mechanisms of cardiac septation and valve development.
MedLine Citation:
PMID:  22912411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart malformations are common congenital defects in humans. Many congenital heart defects involve anomalies in cardiac septation or valve development, and understanding the developmental mechanisms that underlie the formation of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart.
Authors:
Chien-Jung Lin; Chieh-Yu Lin; Chen-Hao Chen; Bin Zhou; Ching-Pin Chang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-22     Completed Date:  2012-10-29     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3277-99     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation, Developmental / genetics,  physiology*
Heart Septum / embryology*
Heart Valves / embryology*
Humans
Morphogenesis / genetics,  physiology*
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